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Vomiting and diarrhea , especially for more than two days, can reduce the effectiveness of oral contraceptives because the medication is not fully absorbed by the body

The epidemiological data on sex differences in acetaminophen-induced liver injury in humans is inconsistent, which can be attributed to confounding factors such as variations in age, dosage, time elapsed from ingestion to hospitalization, and time from ingestion to N-acetylcysteine administration

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doi: 10.1056/NEJM198705073161904

Patients with severe kidney disease or end-stage renal disease may not be appropriate candidates for this therapy, particularly if they have significant fluid retention or are prone to dehydration

The overproduction of COX-2 is inhibited by eicosanoids made from omega-3 fatty acids