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Potential causes include pre-existing vascular ED that was present before tirzepatide but was attributed to the medication, medication interactions with drugs known to cause ED (SSRIs, beta-blockers, spironolactone, finasteride), severe nutritional deficiencies from inadequate intake, or undiagnosed conditions like depression or hypogonadism unrelated to obesity

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Because these drugs affect separate mechanisms, combining them may address multiple weight loss and metabolic issues simultaneously