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Older adults: B12 absorption can decline with age

NICE-aligned management typically involves: Addressing modifiable risk factors (smoking cessation, weight loss, increased physical activity, alcohol reduction) Optimising management of underlying conditions (diabetes, hypertension, depression) Trial of PDE5 inhibitor therapy Referral to specialist services (urology/andrology) if first-line treatments fail or where structural/neurological/endocrine causes are suspected Consideration of psychosexual therapy where appropriate Men should be reassured that ED is a medical condition with effective treatments, and seeking help through proper channels ensures safety, appropriate investigation of underlying causes, and access to evidence-based therapies

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Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations

B12 is essential for the normal function of immune cells, and deficiency has been associated with impaired immune responses

The body responds by clotting to stop blood loss