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Semaglutide is generally well tolerated, but some individuals may experience gastrointestinal symptoms, such as nausea, diarrhea, constipation, headache, fatigue, decreased appetite, and dizziness, which may be due to low blood sugar

doi:10.1542/peds.2008-1173

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That said, in humans the data are less robust than for some other sleep interventions, so effective depends on how you define it (improvement vs complete resolution of poor sleep quality)

Gastric distension-induced release of 5-HT stimulates c-fos expression in specific brain nuclei via 5-HT3 receptors in conscious rats