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GSH serves as an antioxidant, helping to prevent damage to cellular components caused by reactive oxygen species such as free radicals and peroxides

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Additionally, long-term use of metformin is associated with vitamin B12 deficiency 2

doi: 10.1016/j.jri.2024.104415 26 MikuMGoldtajnMBrleiIDumaniSLaganASChianteraVet al

The early sundowning was confirmed by additional family members and the primary author's observations on multiple occasions during the summer of 2019 while traveling on the same route to his vacation home in Nebraska for weekend trips (3,330 ft., 0.89 ATA)