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The standard protocol begins at 0.25 mg weekly, increasing by 0.25 mg every week until reaching 1.0 mg, then escalating to 1.7 mg and finally 2.4 mg over several months

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Both agencies noted that the reports were rare relative to the large number of patients using these medications and that confounding factors, including pre-existing mental health conditions, major lifestyle changes, and concurrent medications, made it difficult to attribute psychiatric symptoms directly to GLP1 treatment