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Furthermore, its short half-life of less than 3 h (Min et al., 2025) necessitates twice-daily injections to maintain efficacy, which can be a limiting factor for long-term patient adherence

While Semaglutide is excellent for appetite suppression, it lacks the metabolic boost provided by the glucagon and GIP components

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2225 Diabetes is also associated with autonomic imbalance, manifest as parasympathetic withdrawal, and sympathetic dominance, 23 suggesting these patients may be particularly sensitive to drugs which alter autonomic control of heart rate

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