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Beta-3 adrenergic receptors can desensitise under chronic agonist exposure, a phenomenon documented in the context of other beta-adrenergic agonists

Moreover, these leukocyte-endothelial cell interactions can also directly contribute to increase BBB permeability by releasing reactive oxygen species, cytokines, and other mediators of barrier disruption [60]

26 , 969983.e4 (2019)