Red flags that should stop the protocol Certain findings should trigger immediate discontinuation of one or both compounds: IGF-1 levels exceeding the age-appropriate upper normal limit on two consecutive tests Fasting glucose rising above 126 mg/dL or HbA1c above 6.5% (indicating new-onset diabetes) Liver enzymes (ALT or AST) exceeding three times the upper limit of normal Persistent severe nausea, vomiting, or abdominal pain suggesting gastroparesis or pancreatitis New or worsening carpal tunnel syndrome symptoms Peripheral edema that does not resolve with fluid management Any sign of an allergic or hypersensitivity reaction These red flags are not exhaustive
Tirzepatide may produce slightly greater average results based on current data, but semaglutide has a longer track record and may be more accessible
What happens to your appetite after stopping GLP-1 or combined weight loss medications
Unlike compounded tirzepatide, which lacks regulatory oversight and can vary in quality, these FDA-approved options are rigorously tested, ensuring they meet high standards for weight loss therapy
Samuel Lin, an associate professor of surgery at Harvard Medical School and a Boston-based plastic surgeon, tells TODAY.com
Table of Contents: How soon will the effects of semaglutide GLP-1 be noticeable after the first shot
