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Post-Exertional Malaise (PEM) and Crashes: PEM occurs when damaged mitochondria cannot meet the energy demands of even minor physical or cognitive exertion, forcing the body into a toxic, anaerobic state

Many people experience periods where their energy, hydration, or nutritional balance may need additional support

Microglial activation reduction: Retinal microglia (resident immune cells) become activated in disease states releasing inflammatory mediators and reactive oxygen species

Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]

The extent and clinical significance of this effect remain subjects of ongoing investigation, and individual responses vary considerably based on genetic factors affecting pigmentation, baseline skin characteristics, concurrent skincare practices and sun exposure, and overall health status affecting skin appearance