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Excess heme upregulates heme oxygenase 1 and promotes cardiac ferroptosis in mice with sickle cell disease

3 Oxidative stress Oxidative stress is a disbalance caused by excessive production of prooxidant substances such as ROS and RNS and/or the antioxidant systems working inefficiently ( in vivo primarily by the mitochondrial respiratory chain during aerobic metabolism ( via a reaction between nitric oxide (NO) and superoxide, and nitrosoperoxycarbonate, generated via a reaction between peroxynitrite and carbon dioxide

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CT, JM, and MS prepared the tables, while MS, YM, NL, JM, and SL prepared the figures

at 2:00 and I actually felt alive and thinking

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