Induction of Pdh and Pfkp by Exendin-4 was significantly blunted by HIF-1 knockdown (Fig
The anonymous collection of discarded blood samples from SCD children undergoing chronic transfusion was classified as exempt by the Institutional Review Board at Augusta University and did not require informed consent
Many preclinical studies have demonstrated that the expression of key enzymes for GSH synthesis (GCL, SLC7A11, GS) and GSSG reduction-related enzymes (G6PD, NADPH, and GR) is downregulated in myocardium exposed to pathological factors [40, 43,44,45,46,47,48,49,50]
According to previous studies, postnatal high fat (HF) diet can lead to NAFLD through mechanisms including oxidative stress, inflammation, and nutrient-sensing signals [14,15,16]
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