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The primary outcome was C-peptide area under the curve (AUC) during the MMTT (adjusted for test duration), as a measure of residual beta cell function

Traditionally, obesity management focused on lifestyle modifications, including dietary restrictions and increased physical activity

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Lipid Metabolism & 3-AR Mechanism Heffernan et al., Endocrinology (2001) Heffernan and colleagues investigated the lipolytic effects of chronic AOD-9604 treatment using two complementary mouse models: diet-induced obese C57BL/6J mice and beta3 adrenergic receptor (3-AR) knockout mice

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Instead of taking the full amount once a week, you take half the dose each time