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Microscopic Findings Increased melanin in basal cell layer Increased melanin production by normal numbers of melanocytes Melanin incontinence Diagnosis History of chronic, heavy smoking Biopsy Clinical appearance Differential Diagnosis Physiologic pigmentation Addisons disease Medication-related pigmentation (drug-induced pigmentation by chloroquine, clofazimine, mepacrine, chlorpromazine, quinidine, or zidovudine) Malignant melanoma Treatment None Reversible, if smoking is discontinued Prognosis Good, with smoking cessation Cafe-au-lait macules Caf-au-lait macules are discrete melanin-pigmented patches of skin that have irregular margins and a brown coloration

While compounders typically use standard vials and syringes (avoiding these patents), the ease of use of the branded pen is a key competitive advantage for the innovator

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Gonadorelin Gonadorelin mimics natural gonadotropin-releasing hormone to trigger luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from the pituitary