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Serum folate levels were normal (4.97 ng/ml)

As a harmful consequence of free radical accumulation, oxidative stress is frequently observed in patients with PCOS, characterized by elevated reactive oxygen species (ROS) production and diminished antioxidant capacity

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The increase in PyroGlu could be due to three key points: (I) the catabolism of GSH through gamma-glutamyl transpeptidase, (II) and/or to a limiting factor in the second step of gamma-glutamylcysteine synthetase (III) or a limiting factor in the following step involving glutathione synthetase

In addition to their effect on adaptive pathways, at high levels, exogenous antioxidants can promote oxidation, contributing to acute decrements in exercise performance

The glutathione benefits and side effects have made it a topic of great interest in the skincare industry