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Research demonstrated that DNA double-strand breaks in proximal tubular epithelial cells led to weight loss, reduced fat mass, impaired glucose tolerance, mitochondrial dysfunction, and increased inflammation in adipose tissues, suggesting that DNA damage in kidney cells can have far-reaching effects on overall metabolic health (93)

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insulin dose at GLP-1RA initiation was only decreased if HbA1c was below 7.5% (60)

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Zheng D, Li N, Hou R, et al

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