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Reduced glucose, insulin and IGF-1 levels ormore generallyDR activate an energy-sensing network consisting of AMPK, SIRT1, PPAR and PGC-1 with the potential to counteract tumor cell proliferation

doi:10.1016/j.jaci.2012.03.042 Wantke F, Gotz M, Jarisch R

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In one study, men with low testosterone who used TRT lost about 11 pounds of fat and gained about nine pounds of lean mass over 18 months