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Symtoms of severe thiamine deficiency Thiamine derivatives and thiamine dependant enzymes are universally present in all cells of the body thus a thiamine deficiency would seem to affect all organ systems especially the heart and the nervous system due to their high oxidative metabolism as witnessed in its severest form as beriberi (dry, wet or infantile) [195]

Adiponectin increases hepatic insulin sensitivity and oxidation of skeletal muscle glucose and fatty acid, and decreases glucose release [35,36,37,38]