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Quantification of intracellular NAD + /NADH and NADP + /NADPH pools The intracellular pools of NAD + /NADH and NADP + /NADPH were quantified by using the Fluorimetric Amplite TM NAD + /NADH and NADP + /NADPH assays (AAT Bioquest, Inc.)

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Genomic Regulation: It resets the gene expression of the Ubiquitin-Proteasome System (UPS), enhancing the cell's ability to clear toxic proteins (upregulating 41 UPS genes)

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FIGURE 1 2.2.4 Other metabolic pathways Mitochondria play an essential role in the advancement and development of ferroptosis (Martnez-Reyes and Chandel, 2020