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While semaglutide and tirzepatide focus primarily on GLP-1 and GIP pathways, this peptide also activates the glucagon receptor, which boosts energy expenditure and weight reduction

However, 47% of those with diabetes and 36% with obesity who discontinued these medications restarted them again within a year

Kodama H, Asagiri K, Etani Y, et al

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To evaluate the relative superiority of individual regimens, we conducted Bayesian-based surface under the cumulative ranking (SUCRA) evaluations, visualized through Litmus Rank-O-Gram and radial SUCRA plots