A decrease in the activity of GS alone without a change in GCL and a fall in muscle GSH levels were also described after surgical trauma in human skeletal muscle (Luo, et al., 1998)
This is why clinicians working at the intersection of metabolic medicine and longevity treat both simultaneously
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Although acute, short-term CORT elevation has anti-inflammatory effects, chronic stress disrupts negative feedback regulation, leading to increased levels of inflammatory cytokines such as IL-6 and TNF-, exacerbating esophageal mucosal damage and neural sensitivity
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