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The Key Factors in the Methylation Cycle We will now consider three important causes of interruption to the methylation cycle: Vitamin B12 deficiency Folate deficiency MTHFR mutation Vitamin B12 deficiency If vitamin B12 is deficient, the methyl group cannot be transferred from methylfolate to the methionine cycle

Heres a schematic of this conversion: The MTHFR gene is located on the short arm of chromosome 1 (1p36.3) and encodes for dimeric proteins

A B12 deficiency can also be the result of: Cobalamin malabsorption (intestinal diseases, gastric/intestinal resection, atrophic gastritis, pancreatic insufficiency) Low gastric intrinsic factor (dietary intake deficits are less common) Drug interactions

Molecular Weight: Approx

Minimal response may warrant increasing by 50-100mcg

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