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Isothiocyanates are antimicrobial volatiles produced from glucosinolates by myrosinase enzymes (Bones and Rossiter, AbGst1 was up-regulated in planta during infection suggesting the potential involvement of this enzyme in isothiocyanate detoxification mechanisms during host plant infection (Sellam et al., 2006, 2007)

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This hypoxic and acidic microenvironment in metabolically altered GBMs affects radiotherapy efficacy and drug delivery, and plays a crucial role in biological mechanisms involved in cancer progression and treatment resistance, such as aberrant DNA repair, angiogenesis, and cancer stem cell maintenance [5,6,7,8,9,10]

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