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No significant increase in gastroparesis diagnosis was detected compared to placebo groups in any pivotal trial
Hansen, Roeland F
While tirzepatide made history as the first dual GIP/GLP-1 receptor agonist to receive FDA approval, retatrutide pushes the pharmacological envelope further with triple receptor agonism that adds glucagon receptor activation
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In humans, satiety was increased and food intake was reduced after IV infusions of physiological doses of GLP-1 during meals (58, 59)
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