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Most experimental patches use microarray technologythousands of tiny needles that penetrate the outer skin layerbut this still requires regular replacement and carries infection risks similar to injections

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mTORC2 also phosphorylates SGK-1 at Ser422, leading to inhibitory phosphorylation of FoxO3 and other activators of autophagy, such as VDAC1 and ULK1 [296]

Smaller infarcts preserve more functional tissue, which translates to better pumping ability and improved long-term outcomes