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STEP 1, an industry-sponsored study presented virtually at the 2021 Endocrine Societys annual meeting, showed that semaglutide, when administered weekly,

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GLP-1R expression was successfully suppressed in 3T3-L1 adipocytes that were transfected with siRNA targeting GLP-1R, while the scramble control siRNA had no effect on GLP-1R expression (Fig 2A)

Petersen KF, Shulman GI

Timing your injection according to the product instructions is important