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Clinical complications related to liver failure and portal hypertension, such as hepatic encephalopathy, symptomatic ascites, repeated hospitalizations, medication burden, electrolyte imbalances (especially hyponatremia), low sodium diets, and general debility, exacerbate appetite loss (13)

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Emerging evidence delineates central roles of GLP-1 in appetite regulation, neuroprotection, neuroinflammatory mitigation, enhanced intracellular signaling, and cognitive enhancement 72,73,74