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The largest effect size of any non-surgical metabolic intervention in clinical trial history
Int J Clin Exp Pathol 10:13221330 Meng RD, Shelton CC, Li Y-M, Qin L-X, Notterman D, Paty PB et al (2009) -Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity
[PMC free article: PMC2699134] [PubMed: 19221394] 85
The study was supported by a grant from the European Research Council (grant no
Similarly, in the CANVAS outcome study, discussed in detail below, LDL cholesterol and HDL cholesterol were also marginally increased in the canagliflozin treated group (LDL cholesterol 4-5 mg/dL and HDL cholesterol 2-3 mg/dL) (144)
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