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Gastrointestinal Side Effects The most common adverse events were gastrointestinal in nature, as expected for this drug class: Nausea the most frequently reported GI side effect, typically most pronounced during dose escalation and diminishing over time Diarrhea reported at moderate frequency Constipation less common than nausea but clinically relevant for some participants Vomiting generally mild and often transient These GI effects are mechanistically linked to GLP-1 receptor activation (slowed gastric emptying, central appetite suppression) and are a recognized feature of all GLP-1-based therapies

Set a schedule for hydration to ensure your kidney remains well-perfused with blood

Let the inflammation settle and the skin barrier stabilise

In OASIS 4, one in three participants experienced at least 20% weight loss

Although CPAP remains the standard first-line therapy for OSAS, the combination of tirzepatide and CPAP is emerging as a promising integrated treatment approach

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