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Normal and expected reactions include a brief stinging or burning sensation during or immediately after injection, mild redness or warmth at the injection site lasting a few minutes, and small temporary lumps that resolve within 30 to 60 minutes as the solution disperses through subcutaneous tissue

Also, melatonin receptors are transiently expressed in neuroendocrine tissues during development, suggesting that melatonin has a role as a neuroendocrine synchronizer in developmental physiology (44)

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Caruso I, Marrano N, Biondi G et al (2023) Glucagon in type 2 diabetes: friend or foe

Thigh: Some individuals find the thigh offers more control during the injection process