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We stated that CMS has historically had to rely on survey data due to a lack of other more reliable sources of information, but in recent years many new methods to identify empiric inputs used in valuation have been developed

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The dose per unit is: Dose per unit = Concentration (mg/mL) x 0.01 mL Or equivalently: Dose per 10 units = Concentration (mg/mL) x 0.1 mL This math is universal

11 Solid evidence on the safety of parenteral, lifelong, high dose hydroxocobalamin is available from decades of treating patients with inborn errors of B 12 metabolism (eg, cobalamin C deficiency)

Heart Lung , 46 (2), 120128