The imbalance between reactive oxygen species (ROS) and antioxidants leads to cellular damage through lipid peroxidation, protein oxidation, and DNA injury, ultimately triggering inflammation, apoptosis, and structural damage within ovarian tissue
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For example, tissue-resident pancreatic stellate cell-derived cancer-associated fibroblasts (CAFs) secrete lipids, such as lysophosphatidylcholines, which promote the absorption and synthesis of phosphatidylcholine by cancer cells [28]
Recently, owing to their special spatial structures, peptide-based macrocycles have shown tremendous promise and aroused great interest in multidisciplinary research ranging from potent antibiotics against resistant strains to functional biomaterials with novel properties
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