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10.1007/s00405-021-06628-5 39 LeeH

Mitochondrial quality control in lung diseases: current research and future directions

Other pharmacological options include catechol-O-methyltransferase (COMT) inhibitors like entacapone and opicapone, which extend the half-life of levodopa, do not cross the BBB at all and primarily affect peripheral metabolism, providing no direct action in the brain 59

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A hint to their possible formation is to consider that the thioethers of reactive electrophiles with glutathione, cysteine and N- acetyl-cysteine can undergo in the kidney a -elimination reaction to yield a thiol compound and a reactive, electrophilic dehydro-alanine derivative

14 No current UK marketing authorisation for a GHK-Cu medicinal product was identified in the official sources checked for this guide