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Two melanocortin receptors (MC3R and MC4R) are expressed in the brain, although both have been implicated in the regulation of energy balance, MC4R has a predominant role in the regulation of food intake ( A large number of studies has shown that central administration of alpha-MSH and Melanotan II (MTII), a non-selective melanocortin 3/4 receptor agonist, strongly reduces food intake and increases energy expenditure

The best-known telomerase findings come from cultured human cells