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NICE first recommended the drug in draft guidance 2022, after a clinical trial of just under 2000 volunteers found that people lost on average 12% more weight with semaglutide alongside supervised weight loss coaching (BMJ 2023;380:556)

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Patient education : Provide written and verbal instructions

[4] [13] This delayed emptying creates a prolonged sensation of fullness after meals, which contributes significantly to reduced caloric intake

If glucose is consistently above 250 mg/dL, especially with symptoms like nausea, vomiting, abdominal pain, rapid breathing, or fruity breath odor (signs of diabetic ketoacidosis), seek urgent medical care