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No trial has established one step-down schedule

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Nitrogen adsorption-desorption isotherms at 77 K were measured using a Micromeritics TriStar sorptometer (Micromeritics Instrument Corporation, Norcross, GA, USA) to measure the specific surface area, pore size distribution, and pore volume of the samples

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Xiao B, Laroui H, Viennois E et al (2014) Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice

These red flags mean your body requires immediate clinical evaluation and potentially intravenous fluids