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84 A well-controlled clinical trial demonstrated that, when added to a diet low in saturated fat and cholesterol, pantethine provided an additional reduction in total cholesterol and LDL

In the neonatal period, this ability may be further limited as studies in young rats demonstrated that glutamine synthetase activity is particularly low in the pre-weaning period (91, 92)

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Safety and limitations SGLT2 inhibitors are generally well tolerated but are associated with an increased risk of genital infections [103,104] and, rarely, euglycemic diabetic ketoacidosis [105-107]