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Since many metabolites of phase I are too lipophilic to be retained in the kidney tubules, a subsequent conjugation reaction with an endogenous substrate, such as glucuronic acid, acetic acid, sulfuric acid or an amino acid, results in formation of more polar and hydrophilic compounds that are sufficiently polar to be excreted by the kidneys

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De plus, il a t observ que l'effet de cette complmentation augmente avec le temps, atteignant son maximum aprs environ 6 mois

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