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So that nerves at the back of the eye, and probably every cell type we looked at, perhaps with the exception of eggs and sperms, and certain stem cells, they lose their identity, they dont have what we call a youthful gene expression pattern anymore

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Acute kidney injury has been reported, typically in the context of severe dehydration from gastrointestinal side effects

5,6 Additionally, high glucose levels negatively impact osteoblast function, contributing to bone defects partly through the production of advanced glycation end-products (AGEs), which upregulates sclerostin, an inhibitor of osteoblast activity

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