What are the optimal drug characteristics of a GLP-1/glucagon co-agonist for the treatment of NAFLD via hepatic GCGR agonism
However, the well-recognized pleotropic effects of GLP-1R agonists (normalization of neurogenesis and synaptic plasticity, protection against neuronal apoptosis, and suppression of increased oxidative stress), in conjunction with the presence of GLP-1Rs in the hypothalamic nuclei that regulate sleep and wakefulness, suggest several possible direct effects of GLP-1R agonists in affecting sleepiness and other related parameters (memory, anxiety, and depression) [77, 114]
10.1002/mds.25032 332
4.5 RAS blockers inhibit stress responses 4.5.1 RAS, corticotropin-releasing factor, and stress In response to stress stimulation, the subgenual prefrontal cortex is suppressed and the amygdala is activated, which activates the HPA axis (137)
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Lancet 2006