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1 Introduction According to relevant statistics, osteoarthritis (OA) is the most common joint disease in humans, with at least 500 million people worldwide suffering from osteoarthritis, and its prevalence is on the rise as a result of a number of risk factors (e.g., metabolic syndrome, aging) ( More and more studies believe that OA is a local inflammatory joint disease, and synovitis is an important early pathological change ( It is now being found that metabolic disturbances are strongly associated with OA