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Grx1 knockout mice show increased cellular protein S -glutathionylation 42 , and Grx2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells 43

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The prevalence of vitamin B12 deficiency is particularly elevated among patients with T2D, with studies demonstrating that up to 64% of those with DPN exhibit altered (low or borderline) vitamin B12 levels compared with only 17% of patients without neuropathy

Using both probes in the cytosol of severely glutathione-deficient rml1 seedlings revealed an E GSH of about 260 mV in this mutant