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Reactive oxygen species have been determined to be critical inducers of various forms of cell death, which are collectively termed oxidative cell death [5]

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In cell lines overexpressing efflux pumps such as MRP1, MRP7, or Pgp, sertraline increased intracellular concentrations of doxorubicin, vincristine, and paclitaxel, thereby lowering their IC 50 values and restoring drug sensitivity [30, 59]

Complete cell disruption was obtained using a dounce homogenizer