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Intramuscular injections are reserved for cases where oral treatment is insufficient, poorly tolerated, or where deficiency has caused neurological complications

Kraft M, Kraft K, Grtner S, Mayerle J, Simon P, Weber E, et al

References Watanabe JH, Kwon J, Nan B, Reikes A

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As a cysteine prodrug, N-acetylcysteine (NAC) is capable of rapidly replenishing intracellular cysteine pools for GSH biosynthesis, which also enhances the activity of GPX4 (133)

Nevertheless, pharmaceutical companies have pursued the twincretin concept, developing GLP-1/GIP dual agonists such as tirzepatide, an analogue biased in favour of GIP over GLP-1 activity [55], and NNC0090-2746, another analogue with balanced GLP-1 and GIP activity [56]