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A novel oncolytic herpes simplex virus that synergizes with phosphoinositide 3-kinase/Akt pathway inhibitors to target glioblastoma stem cells
The peptide structure includes modifications that resist degradation by dipeptidyl peptidase-4 (DPP-4), an enzyme that rapidly breaks down natural GLP-1
They are molecular messengers
Injection-site reactions: Mild redness, tenderness or irritation
TB-500 is a synthetic peptide based on a fragment of Thymosin Beta-4 (TB-4), a naturally occurring protein found in nearly all human and animal cells
doi: 10.1007/s11306-006-0037-z
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