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GLP-1 is part of a group of hormones called incretins, which increases the release of insulin

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After a meal, our bodies recognize the presence of nutrients which triggers the release of GLP-1 which stimulates the release of insulin while suppressing the release of glucagon to keep blood sugar in check

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23 These symptoms can be severe in some patients, resulting in a pause of dose escalation, and if intolerable GI symptoms continue, a dose adjustment to the previous lower dose or a switch to an alternative GLP-1 RA should be considered

And because these medications are administered via injection, alternative formats like patches may improve adherence if proven safe and effective