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The first drugs to aid in weight loss, such as thyroid hormone, amphetamines (which also suppress appetite), and dinitrophenol, had short-lived success due to the CV effects of thyroid hormones, the potential for abuse with amphetamines, neuropathy, and cataracts with dinitrophenol

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One-way ANOVA, Tukeys multiple comparisons post-hoc test, LFD group excluded

and it really works

Switching to a non-GH peptide (like GHK-Cu) is a different story and generally fine

Patients relying on compounded tirzepatide faced transitions to pharmaceutical-grade products or sought alternative therapies