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Concerning the risks of developing hepatobiliary cancers in FIC-related diseases, they are due to an overexpression of pro-inflammatory cytokines, resistance to apoptosis, and, ultimately, cell hyperproliferation [25]

61 Finally, the effector protein, typically a caspase enzyme, is recruited to the complex and activated, initiating downstream signaling events that lead to inflammation and cell death

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Glutathione peroxidase 4 inhibition combined with chemotherapy or targeted therapy may be a promising therapy for colorectal cancer