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In this meta-analysis, which included 16 studies and 198,404 patients, the authors demonstratedusing primary random-effects analysisthat the DPP-IV inhibitor exposure resulted in a non-significant increase of IBD risk (RR = 1.52, 95% Cl = 0.723.23)

Long-term considerations Because these drugs are so new, there are a lot of long-term considerations we dont have solid answers for yet

10.1002/1878-0261.13685 69 KawaguchiT.YoshidaT.HaradaM.HisamotoT.NagaoY.IdeT.et al (2004)

Radiographic midfacial volume changes in patients on GLP-1 agonists

Jensterle, M., Kocjan, T., Kravos, N

For patients who experienced relief from that noise, its return can feel like losing a safety net