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For the analysis involving patients with both T2DM and obesity, we included those who were prescribed GLP-1RAs or control medications within one year following their diagnosis of both T2DM and obesity, between April 2013 and April 2019

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The SURMOUNT-4 randomized clinical trial assessed the effect of tirzepatide discontinuation on the maintenance of weight reduction in adults with obesity and a weight-related complication, excluding diabetes

Additionally, the results they had for high-frequency (parasympathetic) and low-frequency (parasympathetic + sympathetic) measures were all consistent with this pattern of HRV decreasing across the menstrual cycle, to which the researchers attributed parasympathetic withdrawal: This was also consistent with a rise in resting heart rate (HR), which they observed in parallel: A 2015 study performed with 50 young women in India also found all time-domain HRV measures (including RMSSD, the parameter used by Training Peaks partner ithlete ) were higher in the phase before ovulation than after, during the secretory phase

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And, for the most part, I still believe that